Metaglip review: useful medical facts for patients

Few people think about their blood glucose level. Even fewer people undergo diagnostic procedures to determine it. This even though sugar level is one of the most important indicators of human health. It shows the energy metabolism of the body. With an increase in blood glucose, a dangerous disease called diabetes develops. Its complications can seriously harm a person. In some cases, they are fatal. That is why annual diagnosis is very important. It allows you to determine the development of diabetes in the early stages and prevent its severe forms. In a pre-diabetic state or with a slight excess of blood sugar, endocrinologists prescribe treatment, primarily aimed at changing lifestyle. In some situations, they may prescribe specialized medicines, such as Metaglip.

Drug indications

Metaglip is an effective and safe hypoglycemic drug developed by the American pharmaceutical company Bristol-Myers Squibb (BMS). Endocrinologists prescribe it to patients for the treatment of type 2 diabetes. The drug perfectly complements the diabetic diet and physical activity, allowing you to lower the level of glucose in the blood and stop it within the acceptable range. An important feature of Metaglip, which distinguishes it from similar drugs, is the presence of two active substances: Glipizide and Metformin.

Glipizide acts on the pancreas, increasing the amount of insulin produced. Metformin acts differently. This active substance reduces the absorption of glucose in the body. Moreover, the liver reduces its production. Thus, the drug effectively helps lower blood sugar. Both active substances act on various body systems without interfering, but rather complementing each other. Therefore, Metaglip is so effective against type 2 diabetes.

What is the dosage form?

Bristol-Myers Squibb produces Metaglip in the form of tablets, which vary in the volume of active substances. The tablets have the same biconvex oval shape, on one side of which the abbreviation “BMS” is engraved. However, there are the following differences, depending on the amount of Glipizide / Metformin:

  • When the amount of active substance is 2.5 mg / 250 mg, the tablet has a pink color and the inscription “6081”
  • When the amount of active substance is 2.5 mg / 500 mg, the pill has a white color and the inscription “6077”
  • When the amount of active substance is 5 mg / 500 mg, each tablet has a pink color and the inscription “6078”

Tablets are packaged in blisters, which are located in cardboard packaging.

The composition of the drug

Metaglip is composed of 2 active substances: Glipizide and Metformin. The volume of the first varies from 2.5 mg to 5 mg. The volume of the second is 5 mg. In addition to them, each tablet contains components that form its shell. They are completely safe and do not harm human health.

How should I take Metaglip?

The patient must strictly follow the recommendations of his doctor. The endocrinologist will be able to determine the daily dosage based on the degree of development of type 2 diabetes, weight, age of the patient, as well as the course of treatment. However, the minimum dose is 2.5 mg / 250 mg per day. Metaglip should be taken orally during meals, with plenty of water. Taking the medicine is carried out 1 or 2 times (depending on the daily dose). After a few weeks of using Metaglip, the volume of the drug may be increased. It all depends on the course of treatment and stabilization of blood glucose levels. If the minimum dosage is enough for diet and physical exercise to keep sugar in acceptable values, then increasing the volume of the drug is impractical. Otherwise, the endocrinologist will increase the daily dosage. In any situation, the maximum permitted dosage per day is 20 mg / 2000 mg.


Clinical studies conducted during drug certification have confirmed the safety of Metaglip. However, like any other medical product, it has some contraindications for use:

  • Acute renal failure
  • Diabetic ketoacidosis (with or without coma)
  • X-ray procedures
  • Chronic alcoholism
  • Hyponatremia
  • Surgical operations
  • Pregnancy
  • The period of breastfeeding
  • Age less than 18 and over 65 years

Given the above situations, endocrinologists will prescribe the treatment without using Metaglip. This is why it is very important to tell your doctor about all the disorders that bother you besides type 2 diabetes.

What are the side effects?

Metaglip is generally a safe and non-toxic drug. However, an overdose or individual intolerance to the components can lead to the development of the following side effects:

  • Nausea
  • Diarrhea
  • Stomach ache
  • Dizziness
  • Allergic reactions

These are the most common side effects that are observed in patients. In some rare situations, signs of hypoglycemia or hyperglycemia may occur. If you feel such symptoms, stop taking the Metaglip immediately and contact your doctor. He will adjust the daily dosage, or prescribe another drug.

Metaglip interactions with other medicines

Metaglip actively interacts with other medicines. As a result of the symbiosis, the hypoglycemic properties of the drug may increase or decrease. This can lead to dangerous situations. Therefore, it is very important to inform your healthcare provider about all the medications you are taking. Only a specialist will be able to determine the compatibility of the required drugs and, if necessary, to select more suitable drugs.

Storage conditions

Metaglip should be stored in a dark, dry place out of the reach of children. Subject to all storage rules, the shelf life of the drug is 3 years from the date of manufacture. If this period is exceeded, the drug should be disposed of. It is strictly forbidden to use expired Metaglip.

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