Most people will be surprised if they are told that they are at risk for diabetes. Unfortunately, this is true. Almost every person can develop this unpleasant disease. That is why it is important to check your body for glucose levels every year because with its increase you will not be able to feel the first symptoms of impending danger. Only laboratory tests can show that you are in a prediabetic state. After making this diagnosis, the attending physician will be able to prescribe the correct course of treatment to prevent the further development of diabetes. Most often, it includes the use of specialized medicines. Our Januvia review will give you comprehensive information about one popular drug that endocrinologists prescribe to patients.
Table of Contents
What is Januvia?
Januvia is a well-known hypoglycemic drug developed by the American Merck & Co. Inc. Endocrinologists use it in the treatment of type 2 diabetes. The main active ingredient of the drug is Sitagliptin. Once in the human body, it begins to affect the intestines, stimulating the production of special hormones Glucagon-like peptide-1 and GIP. These are very specific hormones that begin to affect the pancreas with an increase in blood sugar. As a result of such exposure, the body begins to increase insulin production. Thus, the natural regulation of glucose in the blood occurs. The more blood sugar, the more insulin is secreted, and vice versa. This is an important feature of Januvia, which distinguishes the drug from competitors because, with this approach, a person will not have signs of hypoglycemia. Endocrinologists prescribe Januvia in several cases. Firstly, it is great as an additional monotherapy for a diabetic diet and specialized physical exercises. As a result of such treatment, the glucose level stabilizes and stays in the recommended range. Secondly, in more severe forms of type 2 diabetes, Januvia is prescribed as an additional medicine in combination with another hypoglycemic drug.
What does medicine consist of?
The main active ingredient of Januvia is Sitagliptin. Its dosage varies from 25 mg and 50 mg to 100 mg. Each tablet also contains auxiliary components that form the shell. All the ingredients of the drug are safe to use and do not harm the patient.
Merck & Co. Inc manufactures Januvia in the form of round biconvex film-coated tablets. Their color depends on the amount of active substance. The drug is a light pink color has 25 mg of an active substance. A tablet of light beige color contains 50 mg and of beige color 100 mg of the active substance. Januvia is packaged in blisters for 14 pieces, which are contained in environmentally friendly cardboard packaging. Their number depends on the final volume of the drug.
Dosage and Administration
The recommended daily dosage for monotherapy is 100 mg. The patient should take the medicine orally, drinking plenty of water. Januvia can be taken independently of food intake, as the medicine has good bioavailability. In the case of combination therapy, the dosage should be calculated taking into account the use of other hypoglycemic drugs.
If you missed the medication, then correct this situation as soon as possible. It is worth remembering that you cannot take a double daily dose in one day, otherwise side effects may occur due to a possible overdose.
Particular attention should be paid to patients with renal failure. If the patient suffers from a similar disorder, then the daily dosage will be calculated individually and can reach 25 mg.
In any case, the patient should adhere to the recommendations of his attending physician and not self-medicate.
When should you not use Januvia?
Januvia differs from its competitors not only in its specific effect on the body but also in its high safety. Clinical studies have shown that the components of the drug rarely harm a person. Nevertheless, there are several contraindications for use, in which the patient will not be able to take the medicine, for example:
- Acute renal failure
- Diabetic ketoacidosis
- An insulin-dependent type of diabetes (type 1)
- Individual intolerance to the ingredients of the drug
- The period of breastfeeding
- It is forbidden to take Januvia for persons under 18 years of age
These situations do not allow the use of Januvia for a therapeutic course. An endocrinologist will prescribe another hypoglycemic drug.
What are the side effects?
As we already wrote, Januvia is a non-toxic and safe drug. It is well tolerated both in monotherapy and in combination with other hypoglycemic drugs. Clinical studies have shown that side effects appear in only 1-2% of the total patients taking the medicine. Here are the most common negative manifestations:
- Abdominal pain
When these symptoms appear, stop taking Januvia. The patient should consult a doctor. In most cases, the endocrinologist will simply adjust the daily dosage of the drug.
Sitagliptin does not interact with other active substances, so it can be taken simultaneously with various medicines without any risk to health. Nevertheless, experts advise you to always consult a doctor in such matters. Only a specialist will be able to evaluate the specifics of the combined use of drugs and approve it.
Januvia should be stored in a warm, dry place away from children. Subject to these rules, the shelf life of the Januvia will be 3 years from the date of release. It is worth remembering that taking the medicine after the expiration date is forbidden since it can harm health.