What is the danger of diabetes? Of course, first of all, these are various complications that can significantly worsen a person’s health, and in some cases kill him. However, not many people know that the symptoms of a disease are similar to those of other disorders. As a result, the patient seeks help at a time when the development of the disease cannot be prevented. Unfortunately, modern medicine can only reduce the likelihood of complications and bring diabetes into a stable chronic form. You can lead a completely happy life, but for this, you will have to limit yourself to food and take various drugs to maintain a stable level of sugar in the blood. Glucovance is one such medicine. We will tell you why remedy stands out against other drugs, leaving its competitors behind.
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What do we know about Glucovance?
Glucovance is a hypoglycemic drug developed and manufactured by the famous French pharmacological company Merck Sante. The company specializes in manufacturing various anti-diabetes drugs. Glucovance is one of them. The medicine effectively lowers glucose levels to the recommended levels. Therefore, endocrinologists often prescribe it in the treatment of type 2 diabetes. What is the uniqueness of the drug, giving it an advantage over competitors? The answer is simple: the medicine contains 2 active substances, Metformin and Glibenclamide. The first component reduces the production and absorption of glucose, increasing the sensitivity of cells to insulin. The second active ingredient acts on the pancreas, increasing insulin production. Metformin and Glibenclamide have different mechanisms of action, so they do not interfere, but rather enhance the hypoglycemic effect of the medication. Glucovance is great for treating type 2 diabetes in the following situations:
- Standard therapy using diet, exercise and monotherapy did not give a positive result
- Replacing the combination of medicines with one, more effective
In such cases, endocrinologists may prescribe Glucovance as a single drug to lower blood sugar.
Who should not take the medicine?
Using Glucovance is a fairly common practice in the treatment of type 2 diabetes of moderate severity. Nevertheless, the attending physician should carefully examine all chronic disorders in patients before prescribing the drug. After all, it has the following contraindications:
- Surgical operations
- Acute alcohol intoxication
- Type 1 diabetes
- Lactic acidosis
- Hepatic or renal failure
- Women during pregnancy
- The period of breastfeeding
- Age under 18 and over 65 years
For all these cases, medication is undesirable, as it can cause negative changes in the functionality of various organs of the body. It is very important to inform your doctor about the planned pregnancy so that he can prescribe a more suitable drug.
Glucovance dosage form
Merck Sante produces Glucovance in the form of capsule-shaped, film-coated, biconvex tablets. Depending on the content of Glibenclamide, they can be light orange (2.5 mg) or yellow (5 mg). Tablets are packaged in blisters and are located in cardboard packaging in an amount of 30 or 60 pcs.
Composition and components
Each tablet contains 500 mg of Metformin. The content of Glibenclamide varies and maybe 2.5 mg or 5 mg. In addition to active substances, the preparation also includes auxiliary components, among which there is lactose monohydrate, macrogol, titanium dioxide, hypromellose, and iron oxide dye. These ingredients make up the tablet shell and are completely safe to use.
How should I take the drug?
It is necessary to strictly follow the recommendations of your doctor and not exceed the recommended dosage. Endocrinologists prescribe Glucovance with a minimum quantity of 1 tablet per day. In the case of substitution, the drug should be taken following the dosages of the substituted drugs. Experts recommend increasing the daily dose by 5 mg of Glibenclamide every 2 weeks to achieve maximum effectiveness in the treatment of type 2 diabetes. The maximum daily dosage is 4 tablets with an active substance content of 2.5 + 500 mg or 6 tablets for a ratio of 5 + 500 mg.
Drinking alcohol during treatment is prohibited, as it enhances the hypoglycemic properties of the drug. This can drastically lower blood glucose levels and lead to a hypoglycemic coma.
The patient should take the medication orally while eating. When prescribing several tablets per day, it is worth distributing the necessary intake for all meals.
In rare cases, endocrinologists prescribe Glucovance for people over 65 years of age. In such situations, the daily dosage begins with a tablet containing 2.5 + 500 mg of active substances. Doctors gradually increase it, observing the function of the kidneys.
Does Glucovance have side effects? Like any drug, the medication has its negative effects. Most often, they occur with an overdose or individual intolerance to active substances. Doctors most often report the following symptoms:
- Violation of taste (there is a metallic taste in the mouth)
- Temporary visual impairment
- Nausea, vomiting
- Lack of appetite
If these signs appear, you should stop taking the medicine and seek help from your doctor, to adjust the dosage or to replace the drug.
Can I take Glucovance with other medicines?
Metformin and Glibenclamide interact with other active substances. As a result of this combination, the hypoglycemic effect of Glucovance can both increase and decrease. In any case, this does not bring anything good to the patient’s health. Therefore, you must tell your doctor about all the medicines you take while you are taking Glucovance. Moreover, it is necessary to conduct additional consultations in case of prescribing various medicines for other disorders. By acting in this way, you will protect yourself from a dangerous combination of drugs.
According to the instructions, Glucovance should be stored in a dry and warm place to which children do not have access. In this case, the shelf life of the drug will be 3 years. Taking the medicine after the expiration date is strictly prohibited.