Central diabetes insipidus is a rare and unpleasant disease. Unlike diabetes, it is caused by a lack of vasopressin, a hormone that is produced in the hypothalamus of the brain. The main symptoms of the disease are constant thirst and frequent urination. Vasopressin is responsible for retaining water in the body. A person suffering from diabetes insipidus can drink from 3 to 10 liters of water per day. This is a non-dangerous disease, but it brings a lot of difficulties and inconveniences. We will tell you why DDAVP spray is an indispensable tool for people with central diabetes insipidus.
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What is DDAVP spray?
DDAVP spray is a nasal drug manufactured by the American company Ferring Pharmaceuticals Inc. The drug effectively helps with the treatment of central diabetes insipidus and primary nocturnal enuresis. The active substance is Desmopressin acetate. This is a synthetic hormone that makes up for the missing vasopressin. Once in the body, Desmopressin reduces the frequency of urination and also helps retain water. Depending on the prescribed dosage, the patient can use a nasal, tablet or injection dosage form. DDAVP spray is popular among professionals due to its effectiveness and ease of use. You can always carry it with you in your pocket or bag. This will allow you to use the medicine anytime, anywhere. Despite its safety, the drug is sold only through a doctor’s prescription.
What is the composition of the drug?
The main active ingredient of DDAVP spray is a synthetic hormone called Desmopressin acetate.
The dosage form of DDAVP spray
Ferring Pharmaceuticals Inc. produces DDAVP spray in the form of a bottle, packed in a cardboard box. The volume of the drug is 5 ml. The patient receives 10 mg of the active substance in 1 use. Thus, a full bottle is enough for 50 uses.
How to use medicine?
Endocrinologists set the daily dosage of Desmopressin individually for each patient. The deficiency of antidiuretic hormone changes every day, which prevents the establishment of a uniform therapeutic dose. An overdose of DDAVP spray can cause excessive water retention in the body, lowering the level of sodium in the blood. This condition causes various side effects, which we will talk about later.
The recommended daily dosage for adults is 1-4 times spraying (10-40 mg) of the drug per day. Patients can break it down into 2-3 doses at the same time.
Depending on the development of diabetes insipidus, endocrinologists prescribe 1 to 3 sprays of DDAVP spray for children older than 4 years. In this case, experts recommend dividing the daily dosage into 2 doses (20 mg in the morning and 10 mg in the evening). Long-term clinical studies have shown that the drug is safe for pregnant or breastfeeding women. Therefore, they can take the medicine according to the prescribed dosage and not worry about the health of the child.
Experts register addiction to DDAVP spray with a long period of use. It is necessary to consult an endocrinologist if the effectiveness of Desmopressin decreases. Most likely he will increase the daily dosage to the required limit.
Endocrinologists use DDAVP spray as an indispensable tool for the treatment of diabetes insipidus or childhood enuresis. This is due to its high efficiency and safety. The drug has a minimum of contraindications that would prohibit its use. These include:
- Acute heart and kidney failure
- Allergic reactions
- Individual intolerance to Desmopressin
- Children under 4 years old
In all other cases, the patient can use DDAVP spray and not worry about the negative effects. It is very important to inform the doctor about all of your concomitant diseases. The attending physician will advise you and prescribe recommendations for the use of the necessary medicines.
Side effects of DDAVP spray
Side effects are rare. They appear as a result of an overdose or individual intolerance to Desmopressin. Endocrinologists most often record the following negative manifestations in their patients:
- Stomach ache
- Nausea or vomiting
- Difficulty urinating
- Weight gain
If you or your child have these symptoms, you should stop taking DDAVP spray and consult your doctor. Most likely, the endocrinologist will simply lower the daily dosage. In rare cases, he can replace the drug.
Various drugs can enhance the antidiuretic effect of Desmopressin. As a result, there is a risk of excessive fluid retention and hyponatremia. Therefore, the patient should not independently decide on the simultaneous use of DDAVP spray with other medicines. Moreover, you must tell your doctor about all the drugs you are taking. In this case, the endocrinologist will either prescribe another drug or reduce the daily dose.
Storage Terms and Conditions of medicine
Doctors recommend storing DDAVP spray in a dark place protected from children. The temperature should be between 20 and 25 degrees Celsius. Shelf life is 2 years. Endocrinologists strictly prohibit the use of the medicine after the expiration of this period, since it can be harmful.