Benfotiamine – an effective drug for diabetic neuropathy treatment

Diabetes is a well-known disease caused by a significant increase in human glucose. It first appeared in the middle of the last century. But today, diabetes has become a real epidemic. While the World Health Organization is sounding the alarm, many states are spending tremendous amounts of money on treating their citizens and developing new drugs. Unfortunately, this does not help much and the number of patients is growing every year. According to a WHO analysis, by 2025 the number of registered patients with diabetes will approach 500 million. By 2030, this disease will become the 7th cause of death worldwide. Moreover, even those people who adhere to the prescribed treatment may suffer from a large number of complications. Diabetic neuropathy is one of the most dangerous and unpleasant complications. Today we will look at an effective medicine called Benfotiamine.

What is Benfotiamine?

Benfotiamine is a fat-soluble vitamin-like substance similar to thiamine. The chemical properties are similar to vitamin B1. The medicine is rapidly absorbed into the blood when it enters the body and is also actively involved in the metabolism and all processes of human life. Due to its properties, Benfotiamine is used to treat various diseases and significantly alleviates the condition of the patient.

Indications for use

About 90% of all patients have type 2 diabetes. An increased level of glucose in the blood and a chronic course of the disease characterize it. Unfortunately, the disorder cannot be completely cured. Modern drugs stabilize the patient’s condition and reduce the likelihood of complications. However, with particularly severe forms of the disorder, even the most powerful hypoglycemic drugs are not able to return sugar levels to normal levels. As a result, large volumes of glucose begin to slowly destroy the human body, affecting all systems and tissues. The nerve endings and blood vessels are the first to suffer, provoking the development of diabetic neuropathy. This is a disorder of the nervous system that is characterized by damage to the peripheral nerves. The main cause of its development is the destruction of small blood vessels. Depending on the degree of damage to certain nerves, various variants of diabetic neuropathy are observed. However, they are all characterized by the appearance of unpleasant symptoms, for example, loss of sensation, numbness in the limbs, night pains, swelling, etc. Diabetic neuropathy affects 20-30% of all diabetics. This complication leads to gangrene, amputation of the extremities, sepsis, and sometimes-even death. To avoid this, it is necessary to minimize the likelihood of complications.

Benfotiamine increases the activity of a special enzyme, which in a state of hyperglycemia reduces the accumulation of metabolites. They contribute to damage to small arteries, which leads to diabetic neuropathy. Thus, Benfotiamine protects cells and their protein components from the effects of excess glucose. Clinical studies have confirmed the therapeutic efficacy of the drug in the treatment of type 2 diabetes. The medicine not only alleviates the symptoms of diabetic neuropathy but can also serve as its prophylactic.

Dosage form

Pharmacological companies produce Benfotiamine in the form of tablets or capsules. They can be packed both in blisters contained in cardboard packaging and plastic bottles.

Benfotiamine taking

How to take Benfotiamine?

Duration of the course and daily dosage Benfotiamine is prescribed by the attending physician, depending on the degree of development of the diabetic neuropathy. However, you should take the drug orally 1-4 times a day with a large amount of water. Benfotiamine should be taken after a meal. The minimum daily dosage is 150 mg, and the maximum, in the case of treatment of diabetic neuropathy, is 300 mg. For children over 10 years of age, the dose is much less and amounts to 30-35 mg per day. If you missed taking Benfotiamine, the next time you should increase the dose to eventually take the prescribed daily amount. In case of an overdose, allergic manifestations are possible.

The duration of admission is from 15 days to a month. The attending physician can adjust the treatment based on the results.

Side effects

Benfotiamine is a B1 vitamin-like synthetic substance. Clinical studies did not reveal any serious side effects and showed its complete safety. If you take this medicine, you may experience:

  • Various allergic reactions
  • Gastrointestinal Disorders
  • Quincke edema is very rare

As we see, nothing serious. However, if you experience these symptoms, be sure to notify your doctor. Most often, the cause of their appearance is an overdose of Benfotiamine. Therefore, a small dosage adjustment can help correct the situation.

Benfotiamine side effects


In most cases, Benfotiamine is well tolerated by the body even with a significant excess of the daily norm, therefore it has practically no contraindications. Nevertheless, with individual intolerance to the components of the drug, the doctor may cancel the Benfotiamine.

Women should be a little more careful when taking this medicine. The use of Benfotiamine during pregnancy (especially in the first trimester) is possible only after a laboratory-proven lack of thiamine in the body. The doctor must weigh all the risks. The drug can be prescribed if its benefit for a woman exceeds the degree of possible harm to the fetus. During menopause, a woman can take Benfotiamine, but only under the close supervision of a specialist.

Interaction with other medicines

Benfotiamine does not interact with other drugs, so it can be safely used in combination with other drugs. However, we recommend that you consult with your healthcare provider before using two or more medications together.

Proper storage conditions

Store Benfotiamine in a dark and dry place at room temperature. The drug should not be accessible to children. Subject to all the rules, the expiration date will be 4 years. Remember, the use of the medicine after the expiration date is strictly prohibited.

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