Actoplus Met

Actoplus Met review: uses, interactions, dosage and more

How often do we think about blood glucose? How often do we go through special examinations to establish it? The answer is more than obvious to most people: very rare. We begin to think about it only when the doctor reports the presence of diabetes. By the way, the disease kills millions of people around the world every year. Residents of both developing countries and citizens of rich developed countries suffer from it. Every year the disease becomes younger. A few decades ago, people at the age of 20 were not diagnosed with this disorder. But today it is already a common practice. The wrong diet and lifestyle that most people lead are to blame. Despite all the difficulties and dangers, you can live a long, full life with diabetes. It is necessary to strictly follow the recommendations of doctors and take medications that lower blood glucose levels. Today we will consider one of the most effective drugs in this segment. Its name is Actoplus Met.

When should I use Actoplus Met?

In 90% of cases, people suffer from type 2 diabetes, i.e. they are not dependent on insulin injections. Following a diabetic diet and exercising is the basis of the course of treatment. This is enough to stabilize the level of glucose in the blood during the initial stages of diabetes. If they do not help, hypoglycemic drugs come to the rescue. Actoplus Met is a combination drug for the normalization of blood sugar developed by the Japanese company Takeda Pharmaceutical Company Limited. It has two active substances in its composition. These are Pioglitazone and Metformin hydrochloride, which have a different mechanism of action on the body, greatly enhancing the positive effect of the drug. Pioglitazone enhances the sensitivity of body cells and tissues to the produced insulin, resulting in increased energy metabolism and sugar consumption by the body’s cells. Metformin hydrochloride reduces the production of glucose in the liver and significantly reduces its absorption in the intestines. Thus, taking Actoplus Met allows you to more effectively lower sugar levels than do single-component hypoglycemic agents.

Endocrinologists prescribe Actoplus Met to patients with high sugar levels. Due to its high efficiency, this makes it possible to reduce glucose to an acceptable value in a short time. Long-term Actoplus Met allows you to keep it in the required range, without the development of dangerous complications.

Dosage form

Takeda produces Actoplus Met in the form of elongated white coated tablets. On the side of the tablet are the volumes of active substances. Tablets are sold in plastic bottles of 180 or 60 pcs.

The composition of the drug

Pioglitazone and Metformin hydrochloride are the two main active ingredients of the drug. Each tablet contains 15 mg of Pioglitazone and 500 (850) mg of Metformin. In addition to them, the shell also contains magnesium stearate, microcrystalline cellulose, and talk. The safety of using these components has been clinically proven.

How to take Actoplus met

Dosage and administration

Each patient should be careful about taking hypoglycemic drugs. Strictly follow all the doctor’s recommendations if you do not want to experience the symptoms of hypoglycemia.

You must take Actoplus Met with food. This helps to avoid additional disorders with the gastrointestinal tract. The minimum initial dosage is 15mg / 500mg twice or 15mg / 850mg once a day. During the start of Actoplus Met, it is necessary to take blood glucose measurements. This will allow you to assess the degree of its effect and help to adjust the daily dosage. Usually, the doctor changes the dose a few weeks after the start of treatment. In this case, the maximum daily dosage should not exceed 45 mg / 2550 mg otherwise unpleasant side effects or complications may occur.

Try to take medicine if you miss a dose. Do not double the prescribed dose due to skipping. High-calorie or fatty foods do not affect the Actoplus Met, but alcohol is prohibited. Alcohol can significantly reduce or increase blood sugar, leading to hypoglycemia or hyperglycemia. In case of overdose, seek help immediately.

After you start using Actoplus Met or when increasing the dose, carefully monitor your health, especially body weight and heart function.


Endocrinologists note that Actoplus Met copes well with high blood glucose and helps many patients return to normal. Nevertheless, the drug has several contraindications, in which it is unacceptable to use:

  • Serious kidney disease
  • Metabolic acidosis or ketoacidosis
  • Heart failure
  • An allergic reaction to the components of the drug
  • Unsuitable age (up to 18 or older than 80 years)

Women should be especially careful when taking Actoplus Met. As observations show, prolonged use of the drug increases bone fragility, which can lead to fractures and injuries.

Monitoring your blood sugar is very important during pregnancy. The period of breastfeeding is also very ambiguous. Today, there are no studies that would prove the safety of using hypoglycemic drugs. Therefore, only a doctor can weigh all the possible risks and prescribe Actoplus Met during such a period of life.

Actoplus Met side effects

What are the side effects of Actoplus Met?

Clinical trials have shown the safety of using Actoplus Met when all recommendations are followed. However, there is always the possibility of the following side effects:

  • Weight gain
  • Dizziness
  • Nausea
  • Pain in the lower back, side, or bladder
  • Labored breathing
  • Edema in various parts of the body
  • Bruising
  • Unusual fatigue
  • Lactic acidosis
  • Congestive heart failure

The last two symptoms are extremely rare, but they pose a danger to the health and life of the patient. Therefore, if you have any unpleasant signs, stop taking the medicine immediately and consult a doctor for help.

Drug interaction

Actoplus Met actively interacts with various groups of drugs. As a result of combined therapy, its hypoglycemic properties can both increase and decrease. Besides, the likelihood of side effects may increase. To avoid problems, do not make your own decisions about taking several drugs at the same time. It is better to consult with your doctor.

How should I store the medication?

Actoplus Met should be stored in tightly closed packaging to prevent moisture and light from getting inside. Children and pets should not have access to Actoplus Met. The medicine will retain its beneficial properties longer if it is stored at a temperature of 20 to 25° C.

Where to buy Actoplus Met?

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